I currently use a Neo 212 as my primary. If I need a second cab, I have a B410 and a B210. So for the badass look and huge mega sound I use the 410 and 212 stacked together. But after using the B212 for a few years now as my main cab, I would much prefer to have a second B212 and ditch the 410. The tone is better overall. Better bass response from the 12's. And the neo B212 is quite a bit less weight than my ceramic B410, so it saves my back as well. I've been touring with just the 2x12. But if I were to resume touring with 2 cabs, I would buy a second B212 and leave the 4x10 home.
