+1 So much impacts this (strings, amp, playing context, technique) that it is hard to generalize.
One thing I find with the Sadowsky pre is that a VERY little bit goes a long way. I don't think I've ever boosted the treble control at all, since the Sadowsky basses have so much going on up top already, and would never boost that bass control more than 20%... typically less than that.
One thing is for sure, if you crank that bass and treble control, you will get a scoop, and for most amps and players, it will be a boomy, muddy mess. However, just a very, very slight fattening of the low end really adds some nice meat to the tone with most rigs and players... that, combined with the nice buffering impact, sounds great in most mixes.
I did feel the need to get the more mid present single coils for my Sadowsky to really generate the grind and punch I like with my particular technique and approach.
Wonderful basses!