I tried, but did not find it satisfying.
Basically the raw DI tone sucks, you need to dress it up.
So now you enter the rabbit hole which is sound engineering.
There are some plugins which give you an ok sound right away, but the catch is that it will always sound like a record, not like an amp in the room.
Which is to be expected in fact, but it might be acceptable to you or not,
Me, I missed the presence, directness and reactivity of a real amp.
Also if you want your monitors to have the volume and headroom of a bass amp you can multiply its price by an order of magnitude (imho).
Which you might want to do anyway because good monitors are so great, but it's a hefty budget.
Subs are nice but it's hard to integrate them properly into the room, and acoustic treatment to get a good response down low (mine have a -3dB@13hz for instance) is quite the nightmare.
Unless you have a big room and cardboard walls, so if you're stateside you might be lucky. Your neighbors maybe less so
To sum it up I went this way for producing music, it's been quite the adventure and it's far from finished.
So if you decide you want to do this be prepared to spend a lot of time (and money), or to accept big compromises to your sound.
Or just keep a good bass amp around and that's it.