Bottom line: Only you know how your body will react to various chemical agents. Gig often enough through time, and you develop standards, even downright PnP's about substance use/abuse in relation to your gigs.
As for me, I'll do one drink/set. I'm 6'2" 220 lbs, and will sweat a lot of it out anyway. I do love greenery, but not before or during gigs, only after, and only in the privacy of home, once I have gotten there. It is fun to create/noodle/practice by myself with greenery, but not with others, since it might affect my meter. YMMV; this is just my own personal wisdom and self-management strategy that has been developed over 28 years of playing bass, and over 40 years of being a musician.