Completely flat. Everything at noon. I personally believe if you have good equipment you should never have to boost anything to get the sound you want. Both pickups on full ,blend in the middle with flat wounds.
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They are set the same with both tweeters on, the only exception is the overdrive. I have them set a little different flow each other. It really makes a great sound when I need it. My whole thing was I had one and loved it but wanted a fuller sound and get into a 410. And I thought why sell what I already love and have to buy a new head and cab. When I could just double it and I couldn't think of a reason not to. Then went to gc and took my bass and pedal. They let me try it out and everyone was impressed. Bought the second one that day.

Im looking into purchasing a fender rumble 150 combo amp. Would this be good enough for a mid sized gig?
Through my experience of playing a 150 rumble through a 410 cabinet at a rehearsal studio and turning it up 3/4 I think you'd struggle unless you were being DI'd through the PA. if your budget extends then I'd definitely recommend the rumble 350 combo it's very loud and sounds great
Or two of them. Lol.
How's she sound?
Tabdog