I have Chromes on mine and they're the strings that finally made me really satisfied with my L-2500. The bass is made to be pretty aggressive and meaty sounding, no secret there, and I think it does sound best with some trebly bite to it. But I also found that setting it to where I think the tone sounds best also gave me an awful lot of string noise I didn't want from it. So I decided to try a brighter sounding flat to see if I could find that nirvana state of having enough brightness but without the harshness and string noise and I think I found it. I unfortunately only got to play it with the Chromes in a band setting a couple of times before we fizzled out, but it sounded fantastic, even when we had our occasional third guitar player (we played southern rock, so lots of Skynyrd, Molly Hatchet, and Outlaws).
I find that the flats help me keep the treble level up where I think the bass sounds best but without pushing it overboard. Then I can adjust the bass to fit the song/setting. FWIW, my favorite switch setting is bridge/serial/passive, which is one of its deeper and least aggressive settings, so that may also help explain why I like the treble up higher (3/4 to full) and usually keep the bass around 1/2. But I found what I think works well on the bass and I've been pretty happy with it since putting the Chromes on it.
If you want even less brightness, you can go the other direction and try something like Labella Deep Talkin' Flats. I haven't put them on my L-2500 yet, but I would like to give them a try sometime.