I finally zipped up (literally, with zip ties) the idea I've been noodling since I first bought the 4OTF. The JHS Switchback (top right hanging on the back and bottom right red stomp) switches between a clean loop (FEA labs compressor) and a dirty loop (tuner, re/Q and 4OTF). Since I can't see the light on the switchback, having the tuner mute in the dirty loop provides a quick indicator. After the Switchback loops follow the the delay, reverb, and, finally, the Messenger with both DI and line out having separate gains. If you're counting, including the Messenger, I have 3 low passes and 3 high passes--that should be sufficient! I often like the delay but I'm not using the reverb, so it will come off. Also zipped onto the back are two Mission Engineering 529i's, so this is a standalone, no A/C board. You can see above that the re/Q is pumping the 4OTF with clean bass, high mids and treble, which shapes the clean gain around the high pass and low pass, which are filtering some of those out of the drive circuit. So these settings give driven mids with lots of clean bass and top end. That is all independent of my master, always-on 4-band EQ on the Messenger. The two Genzler pedals together vastly increase the available tones, but not all are good. If you're considering running the pair, be prepared to spend some time finding the sweet spots. Some are monstrously awesome, and not easily on tap with the 4OTF alone--in particular pumping in trebles and hi-mids makes more aggressive distorted sounds. The 3 biggest boxes are all lightweight and so is the board, so it's not as chunky as it looks.
(I’m running it on a 12 V power supply.)