Chris, if you like these types of cabs without the tweeters, the drivers do not have any crossover roll off at the upper end, so turning off the tweeter does just provide the full Upper range if the woofers only. As for response comparisons, the 10" has a slightly more vocal mid than the 12", which you would expect from the size of the drivers. And the 210 has remarkable LF depth, more so than you might think in this compact a cab. If you're attracted to 10's, this is your cab.
I would say the mids are a little more mellow in the single 12 compared to the dual 10, which I think you would expect.