yes, +1 to this.
I have a WD800 and a D800+, as well as a Walkabout. WD800 is my go to these days, so I will most likely be trying the Noble through it, both into the front end as well as the FX return and AUX In. Given that the D800+ has become a largely unused backup amp since I got the WD800, I could easily see using it as a just a power amp for the Noble thru the FX return or the Aux In.
I'm also a bit wary of stacking too many EQ's (although I do it all the time with reasonably happy results). I'm going to spend some quality time with the Noble and see how I can make it work best for me and my situation.
I am using a D800+ with Subway 112 and 115 cabs. For a while I used both the Noble and the D800+. For me, when I used both together it ended up being to many EQ points and gain stages. I tried running the Noble into the front end and directly into the FX return. I got better results just using the D800+ on it's own. FWIW I was using a Jazz bass loaded with EMGs.
The Noble is a great piece of kit, especially for recording and in-ear/fly gig situation when paired with a high quality compressor and possibly a cab sim. The MESA is a superb amp with an excellent preamp and DI.