I leave my eq pretty center detent as well. I will sometimes use the balance for a more "P" or "J" kind of vibe, and I will sometimes boost my mids just a touch. Same for fretted or fretless. My P gets a slight tone roll off usually.
I sometimes wonder why I even have an active preamp, but I suppose even "flat" it adds a little something? IDK.

I like the sounds I get with my Roscoes so I'm not going to do anything drastic.
Many years ago I had the thought of playing only passive basses (probably jazz-type basses at that time as I was a real jazz pup guy for a while) and getting a bunch of preamps - Sadowsky, Aguilar, Etc. - and using them for different tones. No HX Stomp back then. Even now, when I see a Sean Hurley or Pino clip I think, why not just play my Classic P with flats for everything. But I guess I'm not Sean or Pino as it just doesn't seem to work for me. It sounds great, but I don't know that it works in our band. My guitar player loves my Century 5. My sound guy loves the P. I only NEED the range of the 5 in a handful of songs. I just can't settle the inner battle of which bass. I need to bring the 5 so I think just play it all night. No one really notices and it's a phenomenal bass. Yet, the simplicity of the P is there as well. Thank goodness I don't have a jazz in play right now. Well, I do but it's not quite as playable as the Roscoes so it doesn't get out as much. Has a lower output as well so swapping is more work as I need a boost preset on my Stomp. The custom wound pups sound great though.
Sorry, got rambling there.