What is it you want out of the 2nd head? The tone? If that's the case, run your Effects out into the other amp and then use its effects out to go back to the other head. In your situation, having 1 head driving both the 2x10 and 4x10 would be your best bet.I trying to find a way to run Two bass heads without running two full 4x10 cabs. as of right now i have a 2x10 200w and 4x10 300w. being that both heads are 400w i'm not really able to run either head into the 2x10 by itself safely. I tried running into the first heads input the out of the pre amp out into the input of the second head but after reading some forums its my understanding that when doing that you bypass the second amps preamps so the tone aren't blending.