I know what you mean with the cab choice. I run mine with Mesa PH410 and it’s beastly too (and heavy as a boulderYes! Channel 2 really eliminated my need for any other OD/Dist. It is so pure and girthy, with as much hair and anger that I could want or need. I usually blend around 5-6 with the gain around 6-7, tweaking as needed, depending on the gig.
I'm running mine through the 610 Pro Neo, which is a HUGE part of the recipe that works for me. I've toured and gigged this rig with everything from OSDM, to funk, to country and there's nothing it can't do. Everyone I've shared the stage with has gushed over it. The crew I'm running with these days, soundman included, have a fit if I bring anything else out!
Sometimes I run MBD2 with hall reverb in front of SB300 and it’s the mightiest shoegazy rig I’ve ever heard.