and there just isn’t a way to notate the key of D# major
There is, it's just kinda ugly:
I've not ever run across anything in D#, but I *did* have one occasion many years back where I was given a part that was in Fb, with a B-double flat indicated in the signature. I have no idea what (aside from pure misanthropy) would possess the arranger to choose that key instead of E.