I do all my eq tweakings on my boss gt1b. My amp is always flat, is there only for amplifi my signal. So, when playing live I send my signal through PA and use my amp as monitor and now is when I tweak the AMP eq settings...some places are more bassy than others so I cut or boost frequencies to hear me good while performing. Cause I know the sound I crafted home or on rehearsals is going ok through PA...so sometimes it's an advantage having two different sounds. I don't know if you get my point haha...
