When I'm sound designing I have different groups some with speaker sim on for going direct or iem and some speaker sim off when using an amp. I also have different groupings for different situations cuz I play in different situations.
That reminds me - although I've not utilized it yet, I keep forgetting the MS60B+ can send both cab sim effected and non-cab sim signals simultaneously from the L & R outputs. This is perfect for those who want to send cab sim to FOH and no cab sim to their stage amp. Could be useful for recording purposes too?