With the clean volume at 12:00, it’s likely that the clean blend signal is masking the overdrive. Start with the clean volume all the way down, and add as needed, no more.
The overdrive in hears 1 and 2 are not at all in your face, in some ways it more a texture and rich harmonics tho g rather than gritty.
Can you try the 4 on the Floor without the Keely preamp to test. If the noise goes away, it may be that there is a switching residual (inaudible under most conditions) that is interacting with the rest of the signal change once the additional gain is being used.
What exactly is your signal path?