Unfortunately for me I've had to round out a generic tone that sort of fits most rooms with little tweaking.
My rig stays in the band trailer because I'm riding with someone else a lot, resulting in my waiting til the trailer gets there, and everything set up before working on my sound.
For most gigs I keep my bass and treble in the middle, and pushed up just a bit on the mids.
I have just a brief few minutes before the drummer and guitar player start messing with their stuff, after which we go right into soundcheck.
In that brief time I sweep and cut any trouble frequencies with the paraeq.
I've tried it other ways but for getting the best sound I can without spending more time on it, it works.
It's not ideal but its the best I can do