Just this last week, I did two big stage/smaller venue shows on multi-band "get on get off" tickets.
I took one Neo112 and the MB-F head, thinking, "if it's not lud enough, I'll just ask for foldback thru the monitors.
I was pleasantly surprised to find that one really was plenty, and did the next two small club venues with one cab. These were the 50-150 person type clubs you ask about, and frankly, I always took two cabs in there, just cause I like the vertical stack and what it does for my personal near-field monitoring.
At both these jobs I had the chance to have a buddy sit in so I could go out and hear the room.
The one Neo112 carried both the stage, and the venue effectively, and I'll only be traveling one cab to those joints from here on out.
Keep in mind, these were not loud bands, we were using one Bose stick/two subs for the PA, and only mics went into that. Both guitarist and pianist were using small 112 combos...
I actually rolled bass off from noon to 11 oclock in all these instances. The bassist that sat in rolled it back a bit more than that.