The quote below answers part of my question in that using the effects send does not cut the signal to the WA power section. My other concern is whether I can get an appropriate signal level for a power amp from the WA. I should get off my lazy duff and try it but the crest is part of my home studio so it's a project to get everything unhooked, moved, tested, and put back together.
The way the Mesa topology is set, the Master Volume comes before the FX loop, so by plugging amp 1 into the FX Return of amp 2 you are actually bypassing the Master Volume of amp 2 completely and all volume control will come from amp 1.
You could try getting an XLR to 1/4" cable and use the DI output of amp 1 into the FX Return of amp 2. Then you could use the DI Level control of amp 1 to control volume of amp 2. I think the DI of amp 2 will still work with that setup (though I could be wrong).