For those building higher powered amps for the international market, SpeakOn is by far the most universal choice for safety regulation compliance. It's also short circuit proof and locking which reduces the chance of failure when a 1/4" speaker plug gets pulled out, this is of additional concern to companies that offer long warranties.
There's also the issue of the tip or sleeve of a 1/4" plug accidentally contacting any grounded object, since neither the tip or sleeve are at ground potential in a bridged topology amp (most class D amps are internally bridged) and this could damage the amp. Also, on the higher powered amps, you can get a good jolt when holding the plug when there's a signal present. I have designed amps that swing over 150 volts peak which most folks would find very objectionable.
Then there's the current... at 2 ohms especially, it's not uncommon to find peak currents (at least in the amps I have designed) of 25 amps. This is enough current to exceed the allowable current density at a 1/4" connector. This comes up in safety compliance because this can result in heating of the contacts and arcing with the potential for fire. Not a big issue in smaller amps, but becomes significant as the power of the amp grows. This is the specific reason why I don't use the combination connectors.
If somebody won't consider an amp without SpeakOns, than there are many amps that must be crossed off their list... and the list will grow more once the new global safety regulations come into effect at the end of this year. Since I won't consider designing an amp without SpeakOns, they might as well cross the Subway line off the list and I won't be offended in the slightest.