For me it was quite a surprise actually. I don't have any of the large SA pedals because I have a pair of Eventide H9's and I've not found the need for more delays or ambience. When I got my EQ2 with it's 5 pin midi din ports, it was first SA pedal on my board that isn't attached to my neuro hub. I've had some midi issues with it, which turned out to be a weird power ramping issue with my Strymon PSU's. For that particular pedal, I have to give it a reboot about 10 seconds after all the others. After that it's quite stable. I've found that the SA gear is more affected by power glitches than any of my other pedal brands. I find the the Neuro hub likes to be on midi Ch 1 to be happiest.
I used to get a lot of midi glitches with SA stuff, lockups and freezes. That was until I kicked my Strymon Mobius off my board and fitted a Quadra Thru box. Strymon seem to add a lot of artefacts to a midi signal. To program them over midi is very tedious and taxing compared to any other brand. All my SA gear is on one midi spur, Eventides on another, EHX on another. Since I've got a Faderfox PC4 (to add more live control to my SA pedals), I've put one of my H9's in the same SA Midi spur and it seems to be quite stable. I think my Boss ES-5 seems to work well with my SA gear's midi.
I get occasional lockups using the USB cable on my desktop using Neuro desktop...that's quite unstable. I have to start Neuro Desktop as an Admin every time, especially if I want to create backups or load backups. Sometimes Neuro doesn't shut down properly and I have to kill it off in task manager. As a piece of software it looks like it's got memory leaks to me. I just use it for scene management and patch creation. I find that when my SA pedals are attached to Neuro Desktop via USB, they seems to be more glitchy and need regular reboots, especially when they lock up with the Neuro Desktop. I can't work out if it's the pedals that lock and cause Neuro to freeze or the other way around.
I find my Aftershock is the least responsive with midi CC for some reason. It jumps a lot and doesn't track well with expression over midi cc. It's just not usable, where as my Lunar (same gen hardware) has no issues at all. These days I do my swells with my EQ2...which is great for that, very sensitive, reactive and low latency. However the best for Expression Midi CC responsiveness is the EHX Hog2. The Aftershock's midi map isn't great, there's no over all level or drive, only channel level or drive. There's also no way to call the 6 internal patches (Midi PC change) over midi, you can only change scenes on a neuro hub. You can send Midi CC to change the distortion model within a patch though, but then all the other internal dials need a re-dial in to make the patch work. The C4, Spectrum and Ultrawave seem to track Midi CC way better than my AS and (for me) seem a lot more stable. When I first got my Neuro Hub, I had to set it as Midi Ch 1 (it was the only way it worked back then) and I still keep it there. I've tried to change it a few times (and rewrite all my Boss ES-5 patches too) but it seems to behave better on ch1. Way less glitchy...so I leave it there. In perfect world (having an all Digital / all Midi pedal board) I would assign my Midi Channels in the same order as y pedal chain, just for simplicity. Unfortunately, that's not the case and with 11 midi channels associated, I have to keep a piece of paper to remind me of my loops, Midi Channels, power feeds and most used scenes/patches on my C4, Ultrawave and hub. If I need to make a new patch...out comes the paper work.