I currently have it as buffered, but, Im not sure if it matters with how I am using it in the FxLoop.
I keep the C4 always on. Then I use MIDI commands from the QC to change presets on the C4 and to turn the FxLoop block on and off. So essentially everything is mapped to a single footswitch on the QC:
View attachment 4577519
When I hit footswitch A it turns on an FxLoop block (bringing in the C4 to the chain and changes the preset on the C4 to my "Moog" preset. Then if I hit footswitch B it turns on the FxLoop block and changes the C4 preset to my Octaver (OC-2) preset. All other footswitches turn the FxLoop block off and do their own things. So if I am on footswitch B, the go to H (Dirt) the FxLoop block is turned off (and therefore the C4 is "off" essentially) so forth and so on. With this flow I can keep the pedal itself on all the time.
I will have to experiment with True Bypass to see if I experience a difference.