Since all but the M5 have Thru, so far I don't need a splitter. I was researching splitters before I found out the Beat Buddy has Thru. I guess the Manta also doesn't have Thru, but that's kind of irrelevant since you can't connect it with a standard MIDI cable anyway, and you need the Hub.
Correct, you connect MIDI to the Hub, which then translates it via the sensor cables to the SB2 pedals.
Well, thanks for not going with a ******.com link!

That barebones info is helpful though. So basically, the Mouse/Gecko type of controllers send PC data, and that's also what can be used to change scenes on the Hub? So I have to set it up for changing scenes on the Hub, while also changing the patches I want changed on my other pedals?
Correct. MIDI PC received by the Hub is what causes the Hub to change Scenes.
As far as changing patches on your other pedals using MIDI PC, I cannot say for certain other than the Line6 M5 will definitely change patches automatically. However, it only stores 24 patches maximum so nothing happens if you send it MIDI PC beyond that 24 patch limit. It's a fairly basic device.
I'm going to assume your other boxes can totally change patches via MIDI PC they receive, but I don't know for certain. Again, it's up to the receiving devices to read and act upon the data. Some MIDI aware devices provide a LOT of configuration to deal with incoming (and sometimes outgoing) MIDI data. For example a configurable patch matrix to change to specific patches based on the MIDI PC received as opposed to simply blindly mirroring the local patches with the MIDI PC. So MIDI PC 1 on a device could theoretically change to the local patch 44 if it provided a MIDI matrix to configure that. It's fairly advanced and can be confusing. It's way easier to logically comprehend just configuring all of your devices to follow the same linear patch changes.
So MIDI PC1 changes everything to patch 1. Very logical and easy to keep straight.
So this is true not just of the Manta but of the Orbital as well?
Actually, I discovered the Orbital's current firmware does not yet sync to MIDI Clock. But I'm assuming that change is in the near future.
Also, you have answered a question I had about how the MIDI clock data works. I have always wondered if it was a single command send out when you change it, or if it is continuous. And your comment about precision definitely matches my experience (the Factor series pedals display the BPM when you change it, and sometimes they will be off by 1 BPM, and/or one of them will "flutter" between two adjacent BPM values).
Exactly, you can see this on a lot of devices that sync MIDI Clock. It's fairly complicated how MIDI Clock data is sent.
The important thing are the receiving devices don't know what position in the measure you are in, and the further downstream the device is from the MIDI Clock generating device, the more out of sync they will likely be from the clock in general due to delays physically receiving the data, and potential delays in their computational algorithms. And the MIDI data is jammed in there with all of the other MIDI data, which can further delay the clock computation.
I've seen some Line6 devices, not sure about the Line6 M5 specifically, allow you to still use the local hard tap tempo button to force the local device to re-compute the start of the measure based on the MIDI Clock. This is useful if you have a 1/4 note tremolo or something that needs to be specifically hitting a specific beat within the measure. 2 minutes into a song the MIDI Clock will definitely have drifted off the measures, though the tempo itself will likely still be correct.
Sounds strange, but if you have 6 devices that all see the MIDI Clock and compute it at 128bpm successfully, but each was a split second off receiving the MIDI Clock data (which they will be), the longer the song goes on the more each device will drift, and eventually that drift can become fairly obvious.
It's not as noticeable for triggered tempo effects, such as delays. But it is noticeable for run-on tempo effects like tremolo.
I'm by no means a MIDI guru, I just have slightly more experience with it than your MIDI beginner.

So hopefully some people even smarter than me can fill in any gaps, or correct any mistakes I've spewed.