The setup I'm moving away from is Universal Audio Apollo coupled with Ableton/ MacBook Pro as the central host for processing, effects, sequencing and synths. Ableton providing wet- only signal and getting amp emulation/ front end processing via the UA platform. Have had success touring that rig, but the biggest problem with that type of system is latency... the UA direct is fine, only 1.5 ms but the effects routed from daw can get to be a drag, too noticeable especially if using soft synths in real time which requires even higher buffers.
Moving back to analog summing mixer, the MPC and external sound modules. A big part of what I'm doing is dub mixing once building a foundation of loops etc, which is far more satisfying out of the box despite a bit larger kit to haul. Digital controllers also have the latency issue which makes the response slower, then navigating pages for control parameters, routing of effects to each other on the fly... the amount of controllers needed for the immediacy of a heavily improvised set trumps the format when adding in the aforementioned latency/ timing issues of such a rig, for me.