Good counterpoints made by all, but still, I think the differences in power amp topology make a difference. If not, when I run the preamp of my B-15 through the power amp of my PF350, it would sound the same as when I use the B-15's own tube power amp. Clearly that's not happening

It does sound very good, yes, but not quite the same.
However, Ken, I do think you're right that we should worry about the topology less and about what we're hearing more as different amps don't sound alike even when the topology is the same.