I commute 160 miles (round trip) every day from central KY to Louisville. About 2/3 of it on back road twisties. My biggest risk is deer. In five years, my wife and I have "harvested" three deer two raccoons and at least 30 bunnies. I've followed various forms of farm equipment for fairly long distances. I consider them one of the charms of the area.I don't have 'freeways', but deer, and cattle in the road, or a tractor hauling a wagon load of hay a 10 mph (top speed for a John Deere) is common. One simply relaxes and takes it in stride.
But once I hit the freeway, (I-65 for me) I expect freeway etiquette. When I give my lights a quick flash, they think I'm being "agressive" when, in fact, I am observing correct protocol. I often have to pass these flakes on the shoulder.