I have an Epiphone Thunderbird and if I dial all the knobs to max, the highs are very bright and that’s not my preferred sound.
My “at home” standard is to set the neck pickup to 8. That’s the first point where the low end doesn’t make my amp buzz at me like an angry wasp, so I leave it there, which is the perfect balance point for my sound. Bridge pick up is dial in at 6, which just gives my ear the most pleasing results and I blend it all together with the tone at 3. I get the sound I’m shooting for from the bass and the amp EQ is generally flat, maybe a tiny bass boost to 12:30 but I like what I’m hearing.