on both of my electrics I had to fine tune pickup and string height. Any small anomalies in setup seem very apparent. But when you lock things in----
I think this is true for any well designed cab. The more faithful your cabs representation, the more your signal chain matters. All of that starts with the player of course, but can be greatly effected by the set up on the insturment.
String/pickup height and intonation matter so much more when you can actually hear/tell the difference.