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Your All Time Favorite Guitar Solo

Hendrix - Voodoo Chile (Slight Return) from his live album In the West
Van Halen - Hot for Teacher
Django Rheihardt - [anything here really]
Dererk Trucks - Sahib Teri Bandi - Maki Madni from Songlines
Both Duane's and Dickey's solos on In Memory of Elizabeth Reed from Filmore East
Santana - Samba Pa Ti off Lotus [Disc 2]
 
One Clapton played on a performance of "Wonderful Tonight" on Saturday Night Live a long time ago. The solo was one of those "make the audience cry with one note" solos. Perfectly etched passion, anguish, and tone all working together. You can see the posture of the guys in the band change as he starts the solo- 'cause they sensed it was gonna happen there.

Another one is Neil Young's solo on "Keep On Rockin' In The Free World", also from an SNL performance. Frank Sampedro on rhythm guitar, Charlie Drayton I believe on bass and Neil gives one of the most emotional expressions ever on guitar.

Clapton's second solo on "Let It Rain" from his first solo album. It's the very reason Leo invented the Stratocaster.

Duane Allman's long solo bit on "You Don't Love Me" from the Allman Bros. Fillmore Concerts. It's about the only unaccompanied guitar solo in a rock or blues vein that I can stomach- and it's mesmerizing. His touch, his expression, his tone, his dynamics, and the emotion that comes across is still an inspiration.

John
 
I'd have to go with "The Joker" by Steve Miller and "Fall to Pieces" by Velvet revolver.
I love the way steve uses the wah and slide together to get some serious expression going and Slash has always been one of my favorites but this solo is so incredibly tasty
 
So many, but some include:

Pat Martino - "Boundaries", "Just Friends, "Along Came Betty"

Jimmy Herring - "Compared to What" (with the Aquarium Rescue Unit), "Eyes of the World" (with Jazz is Dead)

Frank Gambale - love his live solos on "Got A Match" (with CCEB)

George Benson - so many including "World is a Ghetto", "Full Compass", "Benny's Back"

Bireli Lagrene - "Living Hope" (with Front Page), "Hips House" intro

Grant Green - many I like including "Jean de Fleur", "Nomad"

Steve Vai - "Touching Tongues"