I mean, yes, you can certainly try to emulate it, and Opus will give you the means to do so. As someone who owned an old, old Ampeg B-18 fliptop for about 15 years, and was very familiar with the feel and sound of a full-tube rig (also used to plug into a full Traynor YBA tube rig at a rehearsal space for ~5yrs), I can say with certainty that Two Notes, or anybody doing modelling, has not gotten anywhere near what the actual feel and sound is like. The preamp sections are far more convincing, but getting pushed power tube emulation that feels realistic is seemingly much harder to do.I've never owned or played through a full tube amp, nor do I see a chance to do this in the future.
Baring that in mind there is a lot of discussion about the magic of power amp saturation/overdrive. Not having witnessed this phenomenon could I use the Opus into the effects return of one of my solid state amps to emulate realistic power amp saturation?
In fairness, that didn't stop me from selling the Ampeg, and moving away from tube power sections; getting even a relatively quiet 60w amp like that to a point where the power tubes were properly cooking is pretty much impossible in most non-stadium, or studio, spaces. A "properly" loud amp, rated in the hundreds of watts, would be even more of a challenge. So you can lug all that heavy iron around all you want, but good luck being able to take proper advantage!